compliance issues reimbursing glp-1 weight loss treatments multiple states overdoses have been skyrocketing, with poison centers seeing a nearly 1500% increase in calls related to overdose or side effects of injectable weight-loss drugs since 2019, according to US National Poison Telehealth booms on surging GLP-1

Int J Mol Sci 21(22):8695

After Reconstitution (Liquid Solution): This is when the clock really starts ticking

If you experience any severe side effects or signs of an allergic reaction, seek medical attention immediately

This is more likely with higher or sustained doses and is usually reversible once therapy is discontinued

Its pathophysiology involves multiple interconnected mechanisms, including monoaminergic neurotransmitter depletion, impaired neurotrophic signaling, neuroinflammation accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and glutamate-induced excitotoxicity (Medeir et al., 2020)